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Semaglutide is a GLP-1 analogue with 94% sequence as same as human GLP-1. Semaglutide acts as a GLP-1 receptor agonist that selectively binds to and activates the GLP-1 receptor. Semaglutide reduces blood glucose in a glucose-dependent manner by stimulating insulin secretion and lowering glucagon secretion when blood glucose is high. The mechanism of blood glucose lowering also involves a minor delay in gastric emptying. During hypoglycemia, Semaglutide diminishes insulin secretion and does not impair glucagon secretion. Semaglutide reduces body weight and body fat mass by an overall reduced appetite. Buy Orsema Online In Australia, UK, and CA with a Credit Card.

Indications

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• An adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

• To reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus and established cardiovascular disease

Dosage & Administration

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The starting dose is 0.25 mg of Semaglutide once weekly. After 4 weeks the dose should be increased to 0.5 mg once weekly. After at least 4 weeks with a dose of 0.5 mg once weekly, the dose can be increased to 1 mg once weekly to further improve glycemic control. Weekly doses higher than 1 mg are not recommended. Semaglutide is to be administered once weekly at any time of the day with or without meals. Semaglutide is to be injected subcutaneously in the abdomen, thigh, or in upper arm. The injection site can be changed without dose adjustment. Semaglutide should not be administered intravenously or intramuscularly. The day of weekly administration can be changed if necessary as long as the time between two doses is at least 3 days (>72 hours). After selecting a new dosing day, once weekly dosing should be continued.

Precautions

Diabetic ketoacidosis: Semaglutide should not be used in type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. Buy Orsema Online In Australia, UK, and CA with a Credit Card.
Pancreatitis: Semaglutide should be discontinued promptly if pancreatitis is suspected and it should not be restarted if pancreatitis is confirmed.
Diabetic Retinopathy: Patients with diabetic retinopathy should be monitored.

Use in Pregnancy & Lactation

Semaglutide should not be used during pregnancy. If a patient wishes to become pregnant Semaglutide should be discontinued at least 2 months before a planned pregnancy. As a risk to a breastfed child cannot be excluded, Semaglutide should not be used during breastfeeding.

Drug Interaction

Semaglutide delays gastric emptying and has the potential to impact the rate of absorption of concomitantly administered oral medicinal products. Semaglutide should be used with caution in patients receiving oral medicinal products that require rapid gastrointestinal absorption.

OverDose

Overdoses of up to 4 mg in a single dose and up to 4 mg in a week have been reported in clinical trials. The most commonly reported adverse reaction was nausea. There is no specific antidote for overdose with Semaglutide. In the event of an overdose appropriate supportive treatment should be initiated according to the patient’s clinical signs and symptoms.

Storage

Store at 2 C to 8 C (in a refrigerator). Do not freeze. Keep out of reach of children.

Commercial Pack

OrsemaTM 0.25 mg Injection: Each box contains 1 pre-filled syringe of Semaglutide 0.25 mg Injection.
OrsemaTM 0.50 mg Injection: Each box contains 1 pre-filled syringe of Semaglutide 0.50 mg Injection.